T cell dysfunction data portal

Search a gene or protein to view its transcriptomic, whole-proteome, and cysteine-reactivity changes across T cell dysfunction conditions.

Read the manuscript on bioRxiv Vinogradova Lab Vardhana Lab

Experimental schematic: T cells activated with αCD3/αCD28 and cultured under acute or chronic stimulation with IL-7/IL-15, sampled across the dysfunction time course.

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Whole-proteome volcano

Differential protein abundance across the proteome, for the comparison named on the x axis. Each point is a protein; click one to open its per-gene view. Dashed guides mark ±1.5-fold and p = 0.05.

Bulk download

Full processed data as CSV. Fold changes are log₂ from D2, except columns named X_vs_Y, which are log₂(X/Y).